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KMID : 0361020010440090957
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 9 p.957 ~ p.961
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Expression of Cyclooxygenase 1 and 2 in Laryngeal Squamous Cell Carcinoma
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김경환/Kyong Hwan Kim
조강한/이규석/임도형/백상흠/양훈식/홍영호/김미경/Kang Han Cho/Kyu Suk Lee/Do Hyoung Lim/Sang Heum Paik/Hoon Shik Yang/Young Ho Hong/Mi Kyung Kim
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Abstract
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Background and Objectives : A large body of evidence from a variety of experimental systems suggests that cyclooxygenase-2 (COX-2) is important in carcinogenesis. This study was to determine whether cyclooxygenase-1 (COX-1) and COX-2 were
overexpressed
in laryngeal squamous cell carcinoma, and discuss the possible causal role of COX-2 in the laryngeal squamous cell carcinoma formation. Materials and Methods : Tissue samples from 21 pateints with laryngeal squamous cell carcinoma were analyzed
by
immunohistochemical staining. Results : There was an elevation of COX-2 in the laryngeal squamous cell carcinoma formation. Materials and Methods : Tissue samples from 21 pateints with laryngeal squamous cell carcinoma were analyzed by
immunohistochemical staining. Results : There was an elevation of COX-2 expression in laryngeal squamous cell carcinoma. Normal buccal mucosa biopsies and normal laryngeal epitheliums adjacent to laryngeal cancer showed nondetectable or weak
staining
for COX-2 protein. There is no difference in the expression of COX-1 in the normal buccal mucosa, normal laryngeal mucosa and laryngeal squamous cell carcinoma. Conclusion : There is an overexpression of COX-2, but not COX-1 in laryngeal squamous
cell
cancer. This may represent a causal role of COX-2 in the formation and proliferation of laryngeal squamous cell carcinoma. There may also be another role of selective COX-2 inhibition for treatment of laryngeal squamous cell carcinoma.
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KEYWORD
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